Brent Scott

Brent Scott, MS, CSCS

Graduate Student

UMass Amherst

About Me

I’m Brent. Currently, I am a graduate student at the University of Massachusetts Amherst studying molecular physiology and biophysics within the Kinesiology department. I am a member of the Muscle Biophysics Lab and use in vitro techniques to explore force generation in molecular motors.

Research

Graduate Research Assistant
2016 - Present · Muscle Biophysics Lab (UMass Amherst)
My current research is in the field of single molecule biophysics. More specifically, some of my interests include investigating the molecular mechanisms underlying the regulation of force generation and energy transduction in skeletal muscle myosin II and its associated regulatory proteins, troponin and tropomyosin.
Undergraduate Research Assistant
2015 - 2016 · Neuromuscular Physiology Lab (Vanderbilt University Medical Center)

Teaching

Courses Taught
UMass Amherst · KIN 110 (Human Performance & Nutrition); KIN 470 (Exercise Physiology)
Graduate Teaching Assistant
UMass Amherst · KIN 100 (Introduction to Kinesiology); KIN 110; KIN 394 (Applied Exercise Testing)

Education

Pursuing Ph.D. in Kinesiology (ETA Spring 2022)
2019 - Present · University of Massachusetts Amherst
Thesis: What is the relative timing between myosin's powerstroke and phosphate release?
M.S. in Kinesiology
2016 - 2019 · University of Massachusetts Amherst
Thesis: Tropomyosin-Based Effects of Acidosis on Thin-Filament Regulation During Muscle Fatigue
B.S. in Exercise Science
2012 - 2016 · Belmont University

Publications

Journal Articles

2021. Scott B, Marang C, Woodward M, & Debold EP. Myosin's powerstroke occurs prior to the release of phosphate from the active site. Cytoskeleton. https://doi.org/10.1002/cm.21682.

2020. Gunther LK, Rohde JA, Tang W, Cirilo JA Jr, Marang CP, Scott BD, Thomas DD, Debold EP, Yengo CM. FRET and optical trapping reveal mechanisms of actin-activation of the power stroke and phosphate-release in myosin V. J Biol Chem. doi: 10.1074/jbc.RA120.015632.

2020. Mike Woodward, Eric Ostrander, Seung P. Jeong, Xiarong Liu, Brent Scott, Matt Unger, Jianhan Chen, Dhandapani Venkataraman, Edward P. Debold. Positional Isomers of a Non-Nucleoside Substrate Differentially Affect Myosin Function. . Biophysical Journal 119(3), 567-580.

Proceedings

2021. Mike K Woodward, Eric Ostrander, Brent D Scott, Christopher Marang, Xiaorong Liu, Jianhan Chen, Dhandapani Venkataraman, Edward P Debold. Enhancing Cardiac Myosin Function with an Abiotic Energy Source. Biophysical Journal 120 (3), 249a.

2021. Christopher P Marang, Brent D Scott, Mike K Woodward, Edward P Debold. Tirasemtiv and dATP Synergistically Reverse the Acidosis-induced Depression of Myosin’s Force and Motion Generating Capacity. Biophysical Journal 120 (3), 60a0.

2016. Coolbaugh C., Bush E., Sabin S., Scott B., Damon B., & Towse T. Rapid Onset Vasodilation in the Leg is Greater in Habitual Endurance Runners. The FASEB Journal, 30(1 Supplement), 761.10-761.10.

Projects

lasertrapr
Automated analysis of laser trap data using R Shiny

Skills

Laser Trapping
Data Analysis (R programming)
In Vitro Motility

Hobbies

  • Spending time with my wife and our kiddos
  • Running, biking, kayaking (really anything outdoorsy!)

Alter-ego